MANUFACTURING OF
BCG PRODUCTS
" A FRENCH HERITAGE "
RABVACCINE based on 25 years of experience in research and industrial production of BCG products (BCG vaccine against tuberculosis/leprosy/meningitis and BCG Endovesical against bladder cancer), decided to create a pharmaceutical company to manufacture its products in France for the following reasons:
- BCG is a French heritage and the product of more than 30 years of work by two great French scientists (Albert Calmette and Camille Guérin). It is the strongest and most effective vaccine against respiratory infections and it has also been on the world market for a century (to be precise, since 1921). As of today, more than three billion children are vaccinated with BCG. BCG is the safest biologic without any risk.
- Despite everything, France has been importing BCG since 2013 and there is no manufacturer of BCG currently in France.
BCG Vaccine
The BCG vaccine is currently produced by more than 40 manufacturers around the world. BCG has never been cloned and there are now several strains “Secondary Seed”. These strains are used in the manufacture of the BCG vaccine according to different BCG culture methods.
Several researchers have endeavored to reconstruct the derivation of the various contemporary strains from the initial stock of the Institut Pasteur (Osborn T.W. 1983). Microbiological differences have been recognized (Milstien JB and Gibson JJ 1990) for a long time and molecular analyzes have revealed particular genomic regions which are found in M. bovis (Mahairas GG et al. 1996), but which appear to be absent in some or all of the BCG strains (Philipp WJ et al. 1996).
Drugs Against Cancer
In France, bladder cancer is one of the most frequent cancers. It occupies 6th place with 13,100 new cases in 2018, of which 81% are in humans. The incidence rates per 100,000 people/year are 14.3 cases in men and 2.4 cases in women (male / female ratio equal to 6.0).
Worldwide, bladder cancer is the eleventh leading cause of cancer and it is estimated that there have been 550,000 new cases, which represents 4% of all cancers. Mortality from bladder cancer is 5 times higher in men than in women, this being largely due to smoking and occupational exposures found in the genesis of these tumors.
RABVACCINE contributes to the fight against this disease by producing the most effective anticancer drugs and especially against the aggressive forms of this cancer.
Laboratory : 5, rue Henri Desbruères, Genopole Campus 1, Bat 7, 91030, Évry - France.
Phone : +33 1 78 05 47 27
Factory : 2, Chemin de Crève-Coeur, 10380, Plancy l'Abbaye - France.
